The Anti-inflammatory effectiveness of a combination of basil leaf extract (Ocimum americanum L) and turmeric rhizome (Curcuma domestica Val) in mice with carrageenan induction

Abstract

Background : Inflammation is the body's response to tissue injury, usually
caused by physical trauma, damaging chemicals or microbiological agents.
Basil leaves and turmeric rhizomes have been shown to be effective as antiinflammatories. The combination of these plants aims to determine the effective
dose as an anti-inflammatory.
Objective: To determine the anti-inflammatory effectiveness of a combination
of basil leaf extract (Ocimum americanum L) and turmeric rhizome (Curcuma
domestica Val) in rats with carrageenan induction.
Method: This study is an experimental laboratory study using 28 male white rats
of the Wistar strain induced by 1% carrageenan. KN using CMC Na, KP sodium
diclofenac, EK dose of 10 mg/KgBW, RK extract dose of 600 mg/KgBW and
EKRK dose composition (2.5: 450 mg/KgBW, 5: 300 mg/KgBW, and 7.5: 150
mg/KgB B ) . Continued with anti-inflammatory power. then data analysis using
SPSS version 26 began with a normality test and a homogeneity test as a
requirement for the one-way ANOVA test.
Results: The percentage results of anti-inflammatory power of KP 28.71%, EK
10 mg/KgBB 33.00%, RK 600 mg/KgBB 33.23%, and EKRK 2.5: 450 mg/KgBB,
5: 300 mg/KgBB, dose 7.5: 150 mg/KgBB respectively, namely 31.21%,
28.65%, and 28.35% . The data obtained were continued with statistical tests
using SPSS version 26. The results of statistical tests using normality and
homogeneity tests were P> 0.05 and the one-way ANOVA test value was P>
0.05.
Conclusion: It can be concluded that the results of this study showed that in all
treatment groups it was proven effective as an anti-inflammatory. So it is hoped
that this study can be used as a reference for further research.