Identification of Antibiotic Dose Appropriateness in Patients with Non-Pneumonia Acute Respiratory Tract Infection at Community Health Center X

Authors

  • Ayu Putri MS Universitas dr. Soebandi
  • Handa Riyatul Masruroh Universitas dr Soebandi
  • Shinta Mayasari Universitas dr Soebandi
  • Wima Anggitasari Universitas dr Soebandi

DOI:

https://doi.org/10.36858/ipj.v2i2.90

Keywords:

Antibiotics; Dose Appropriateness; Non-Pneumonia Acute Respiratory Tract Infection

Abstract

An Non-pneumonia acute respiratory tract infection (ARTI) is one of the most common diseases in the community and a frequent cause of patient visits to healthcare facilities. Based on a preliminary study, non-pneumonia ARTI was among the ten most prevalent diseases at Community Health Center X, with 266 reported cases during the period of January–December 2025. The high incidence of non-pneumonia ARTI has led to increased antibiotic use. Therefore, antibiotics should be used rationally, including through appropriate dosing. Inappropriate antibiotic dosing may reduce therapeutic effectiveness and increase the risk of bacterial resistance. This study aimed to identify the appropriateness of antibiotic dosing in patients with non-pneumonia ARTI at Community Health Center X. This study employed a descriptive observational design with a retrospective approach. A total of 160 patients were selected using purposive sampling. Data were collected from the medical records of patients with non-pneumonia ARTI, and the appropriateness of antibiotic dosing was evaluated based on the Community Health Center X Formulary. Data were analyzed using univariate analysis. The results showed that, among the 160 patients with non-pneumonia ARTI, the largest age group was children aged 0–5 years, accounting for 46 patients (28.8%). Amoxicillin was the most frequently prescribed antibiotic (77%), followed by ciprofloxacin (23%). The most commonly prescribed dosage strengths were amoxicillin 500 mg (48.1%), amoxicillin 125 mg (18.8%), and ciprofloxacin 500 mg (23.1%). The most common dosing frequency was three times daily (76.9%), followed by twice daily (23.1%). Evaluation of antibiotic dose appropriateness showed that all 160 patients (100%) received appropriate antibiotic doses. In conclusion, all patients with non-pneumonia ARTI at Community Health Center X received appropriate antibiotic doses.

References

Arna, Y. D., Haluruk, J. D., Maulana, I., Legi, N. N., Alow, G. B. H., Montolalu, A., Rajab, W., Ndama, M., Tahulending, A. A., Fione, V. R., Sumampouw, J. E., Sya’diah, Y., Taher, R., Brata, A., Masyitah, D., & Ganut, F. (2024). Patofisiologi Sistem Pernapasan dan Kardiovaskular.

Aztriana, Mirawati, Zulkarnain, I., Purnamasari, V., & Abdullah, S. D. J. (2022). The Suitability Of The Precription Of Non-Sterile Concoctions For Children At Ibnu Sina Hospital Makassar : Compatibility And Stability Study. Jurnal Ilmiah Farmako Bahari, 13(1), 49–71.

Chen, T. H. L. J.-J., Wu, C.-Y., Lin, T.-Y., Hung, S.-C., & Yang, H.-Y. (2024). Immunosenescence, Gut Dysbiosis, and Chronic Kidney Disease: Interplay and Implications for Clinical Management. Biomed Journal, 47(2). https://doi.org/10.1016/j.bj.2023.100638.

Effendi, F., & Evelin, A. (2020). Evaluasi Penggunaan Antibiotik Pasien Infeksi Saluran Pernapasan Akut (ISPA) Dengan Metode ATC/DDD DI Puskesmas Beji Depok Periode Januari-Juni 2019. Jurnal Farmamedika, 5(1), 8–13.

Gonzalez, M. A., Uribe, F., Moisen, S. D., Pichardo, A., Selen, A., Welling, P. G., & Painter, B. (2016). Multiple-Dose Pharmacokinetics and Safety of Ciprofloxacin in Normal Volunteers. Antimicrobial Agents And Chemotherapy, 26(5), 741–744.

Ihsan, S., Sabarudin, Nuralifah, Kasmawati, H., Leorita, M., Damu, R., Sudiman, A., Jamsir, A., Hasniar, W. O., Septiyana, W., Mardiani, S., Ariani, E. R., & Ningsih, W. A. (2019). Evaluasi Penggunaan Antibiotik pada Pasien Pediatrik ISPA Non Pneumonia Menggunakan Sistem ATC / DDD di Seluruh Puskesmas Kota Kendari. 5(2), 25–29.

Katzung, B. G., & Vanderah, T. W. (2021). Basic & Clinical Pharmacology (15th ed.). McGraw Hill.

Kemenkes RI. (2021). Peraturan Menteri Kesehatan Republik Indonesia Nomor 28 Tahun 2021 tentang Pedoman Penggunaan Antibiotik.

Lahope, J. M., Sambou, C. N., I, R. T., Untu, S. D., & Rumagit, H. (2023). Evaluasi Rasionalitas Penggunaan Antibiotik Pada Pasien ISPA Non Pneumonia Anak di Puskesmas Airmadidi. The Tropical Journal of Biopharmaceutical, 6(2), 25–30.

Ningrum, D., Mukhlishah, N., & Erika, Y. (2022). Profil pengobatan obat ispa non pneumonia pada anak di puskesmas mantang lombok tengah. Jurnal Penelitian Dan Kajian Ilmiah Kesehatan, 8(2), 106–111.

Patel, K., & Goldman, J. L. (2016). Safety Concerns Surrounding Quinolone Use in Children. The Journal of Clinical Pharmacology, 56(9), 1060–1075.

Purnama, M. I., Putri, N. N., Aprilia, Z. R., & Zola, E. G. (2026). Wheitening Agent Dan Suspending Agent Yang Digunakan Didalam Sediaan Suspensi. Jurnal Kesehatan Unggul Gemilang, 10(2), 107–125.

Putra, I. M. A. S., & Wardani, I. G. A. A. K. (2017). Profil Penggunaan Antibiotika Untuk Pengobatan ISPA Non Pneumonia Di Puskesmas Kediri II Tahun 2013 Sampai Dengan 2015. Jurnal Ilmiah Medicamento, 3(1), 1–6.

Ramadhani, M. A., & Issusilaningtyas, E. (2019). Gambaran Pendampingan Pengobatan ISPA (Infeksi Saluran Pernapasan Akut) Non Pneumonia oleh Tenaga Kesehatan di Puskesmas Cilacap Selatan II. Jurnal Penelitian Dan Kajian Ilmiah Kesehatan, 5(1), 37–45. www.lppm-mfh.com

Sari, W. K., Advistasari, Y. D., & Elisa, N. (2024). Pola Peresepan Antibiotik Untuk Pengobatan Infeksi Saluran Pernafasan Atas (ISPA) Di Klinik X Kota Semarang. Cedekia Journal of Pharmacy, 8(1), 17–27.

Shargel, L., & YU, Andrew, B. (2016). Applied Biopharmaceutics And Pharmacokinetics Seventh Edition. In Mc Graw-Hill Educaton.

Sukarto, R. C. W., Ismanto, A. Y., & Karundeng, M. Y. (2016). Hubungan Peran Orang Tua Dalam Pencegahan ISPA Dengan Kekambuhan ISPA Pada Balita Di Puskesmas Bilalang Kota Kotamobagu. E-Journal Keperawatan, 4(1), 1–6.

Tuloli, T. S., Akuba, J., Djuwarno, E. N., Makkulawu, A., & Ahmad, R. A. (2024). Profil Penggunaan Obat Antibiotik pada Penderita Infeksi Saluran Pernapasan Akut ( ISPA ) di Puskesmas Kabupaten Gorontalo. Journal Syifa Sciences and Clinical Research, 6(1), 9–19.

Tyson, R. J., Park, C. C., Powell, J. R., Patterson, J. H., Weiner, D., Watkins, P. B., & Gonzalez, D. (2020). Precision Dosing Priority Criteria : Drug , Disease , and Patient Population Variables. 11(April), 1–18. https://doi.org/10.3389/fphar.2020.00420

Vidiani, A. A. P. P., Aswara, L. I., Adrianto, M., & Wibowo, A. D. K. (2023). Evaluasi Peresepan Antibiotik pada Pasien ISPA Pediatri Metode ATC / DDD. Jurnal Kesehatan Amanah, 7(2), 2938.

Wade, C. I., & Martinez, T. (2023). Young’s Rule. In StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK554603/

Wibowo, A. H., & Lukas, S. (2024). Evaluasi Pengobatan Pada Pasien Infeksi Saluran Pernafasan Akut (ISPA) Di Puskemas Pasar Rebo Pada Bulan Juli-Oktober 2023. Jurnal Kesehatan Masyarakat, 1(5), 372–383.

Pharmacy journal publication for the July 2026 period

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Published

2026-07-31

How to Cite

Putri MS, A., Riyatul Masruroh, H., Mayasari, S., & Anggitasari, W. (2026). Identification of Antibiotic Dose Appropriateness in Patients with Non-Pneumonia Acute Respiratory Tract Infection at Community Health Center X. Indonesian Pharmacopeia Journal, 2(2), 108–121. https://doi.org/10.36858/ipj.v2i2.90

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