Effectiveness of Homemade Herbal Powder in Reducing Blood Glucose Levels in Diabetes Mellitus Mice
DOI:
https://doi.org/10.36858/ipj.v2i2.97Keywords:
Diabetes mellitus; Blood Glucose; Herbal PowderAbstract
ABSTRACT
Diabetes Mellitus is a disease characterized by the inability of the pancreas gland to produce insulin, which can cause an increase in glucose levels in the blood. Treatment for this disease can be said to be quite expensive and requires long treatment. Noni, red ginger, black cumin, Chinese petai seeds and cardamom contain antioxidant compounds that can reduce blood glucose levels. These natural ingredients can be made into a drink in the form of homemade herbal powder can reduce glucose levels in the blood. This study aims to determine the effectiveness of homemade herbal powder on blood glucose levels. The method used in this research is an experimental method with a pre-post design. This study was divided into 5 treatment groups, namely negative control group, positive control, treatment group 1 with a dose of 400 mg/kg BB, treatment group 2 with a dose of 600 mg/kg BB and treatment group 3 with a dose of 800 mg/kg BB. The sample size was determined using the Federer formula, amounting to 5 individuals in each treatment. The results of analysis using Paired sample T-test showed a p-value of 0.000 or sig value <0.05, which means that homemade herbal powder at doses of 400, 600 and 800 mg/kg BW can reduce blood glucose levels. The compounds contained in herbal plants that function as antioxidants can help absorb glucose and help pancreatic beta cells produce insulin. Homemade herbal powder can reduce blood glucose levels and the highest average reduction was found at a dose of 800 mg/kg BB.
Keywords: Diabetes mellitus; Blood Glucose; Herbal Powder
References
1. Subeki, Muhartono. Pengaruh Pemberian Infusa Kopi dalam Menurunkan Kadar Glukosa Darah Mencit yang Diinduksi Aloksan The Effect of Coffee Infusion in Lowering Blood Glucose Level in Mice Induced by Alloxan. Juke Unila. 2015;5(9):1–8.
2. Dewi F, Afrioza S. Pengaruh Air Rebusan Jahe Merah (Zingiber officinale Var. Rubrum) Terhadap Kadar Gula Darah Pasien Diabetes Miletus di Desa Mekarjaya. Nusant Hasana J. 2022;2(4):148–55.
3. Pangestika H, Ekawati D, Murni NS. Faktor-Faktor Yang Berhubungan Dengan Kejadian Diabetes Mellitus Tipe 2. J ’Aisyiyah Med. 2022;7(1):27–31.
4. Prawitasari DS. Diabetes Melitus dan Antioksidan. KELUWIH J Kesehat dan Kedokt. 2019;1(1):48–52.
5. Ariska. Efektivitas Pemberian Air Rebusan Lidah Buaya (Aloe Vera) Terhadap Kadar Gula Darah Pada Pasien Diabetes Melitus Tipe II. J Telenursing. 2019;Volume 1,(https://doi.org/10.31539/joting.v1i1.537):157–67.
6. Yunitasari N. Pemanfaatan Daun Pandan Wangi, Jahe, Dan Biji Kapulaga Sebagai Minuman Teh Untuk Obat Herbal Antidiabetes. UNES J Sci Res. 2018;3(2):197.
7. Wijayanti AN. Efektivitas Kapsul Ekstrak Buah Mengkudu ( Morinda citrifolia L.) Terhadap Penurunan Kadar Glukosa Darah Mencit ( Mus musculus L.). J Kesehat Pharmasi. 2022;4(1):68–73.
8. Akuba J, Djuwarno N, Hiola F. Efektivitas Penurunan Kadar Glukosa Darah Daun Lamtoro (Leucaena leucocephala L.) Pada Mencit Jantan (Mus muscullus L.). J Syifa Sci Clin Res. 2022;4(1):293–300.
9. Murfat Z. Uji Efektivitas Ekstrak Jintan Hitam Terhadap Penurunan Kadar Glukosa Darah pada Mencit yang Hiperglikemia. J Mhs Kedokt. 2022;2(5):574.
10. Wicaksono AP. Pengaruh Pemberian Ekstrak Jahe Merah (Zingiber Officinale) terhadap Kadar Glukosa Darah Puasa. Majority. 2015;4(7):97–102.
11. Fatimah RN. Diabetes Miletus Tipe 2. J Major. 2015;4(5):93–101.
12. Zega VL, Wowor PM, Mambo C. Uji Beberapa Dosis Ekstrak Buah Mengkudu (Morinda citrifolia L.) Terhadap Kadar Glukosa Darah Pada Tikus Wistar (Rattus norvegicus) yang Diinduksi Aloksan. J e-Biomedik. 2016;4(2).
13. Riyanti H, Simanjuntak SIB, Winarsi H. Aktivitas Glutation Peroksidase dan Kadar Gula Darah Tikus Diabetes yang Diberi ekstrak Daun Kapulaga. 2014;1:153–6.
14. Rashati D, Fajar HBH, Novitasari A. Pengaruh Variasi Konsentrasi CMC Na Sebagai Pengental terhadap Sifat Fisik Sirup Ekstrak Daun Kersen (Muntingia calabura L.). Semin Nas Kesehat Univ Surabaya. 2022;62–8.
15. Deka H, Choudhury A, Dey BK. An Overview on Plant Derived Phenolic Compounds and Their Role in Treatment and Management of Diabetes. In: National Center of Biotechnology Information [Internet]. 2022. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9510143/
16. Rachmatiah T, Nurvita H, D RT. Potensi Antidiabetes Pada Tumbuhan Petai Cina (Leucaena leucocephala (Lam).De Wit). Sainstech J Penelit dan Pengkaj Sains dan Teknol. 2018;25(1):115–8.
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